Evamist.com

Her lifestyle:

Proactive in trying nonprescription solutions for her hot flashes

Her challenge:

Dissatisfied with the effectiveness of OTC remedies
Cautious about hormone therapy

Her priorities:

Finding a treatement for her hot flashes that works for her
Ready to consider prescription estrogen therapy as the next step

Give her the satisfaction she's looking for^*†1

Evamist (estradiol transdermal spray) offers women an appealing way to reduce their hot flashes^*†1

Wait at least 2 minutes after applying Evamist before dressing and at least 1 hour before washing. The estrogen in Evamist spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed Evamist. Young children who are accidentally exposed to estrogen through contact with women using Evamist may show signs of puberty that are not expected (for example, breast budding).

First-time estrogen users appreciate Evamist^§1

Evamist may be right for her

*	As reported in a patient survey of 515 women, 75 of whom described themselves as having tried OTC products.
†	Patients were asked, "How satisfied were you with the over-the-counter hot flash therapies you tried ?" and "How satified are you with Evmist?" Ratings of 1-3 were classified as dissatisfied, 4-7 as satisfied. Mean was 1.8 and 6.4 out of 7, respectively.
‡	Patients were asked, "Do you find the spray application of Evamist more appealing than an astrogen pill/patch/gel?" More than 96% of patients indicated "yes" for each delivery system.
§	As reported in an experiance study of 247 women using Evamist, 90 of whom had no prior estogen use. Patients were asked, "How important is to you that Evamist delivers a low dose of estrogen?"
\|\|	Patients were asked, "Would you recommend Evamist to a friend?"

» References

Important Safety Information

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER, PROBABLE DEMENTIA and UNINTENTIONAL SECONDARY EXPOSURE TO ESTROGEN

See full prescribing information for complete boxed warning

Estrogen-Alone Therapy

•	There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens
•	Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia
•	The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT)
•	The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older

Estrogen Plus Progestin Therapy

•	Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia
•	The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism, and myocardial infarction
•	The WHI estrogen plus progestin study reported increased risks of invasive breast cancer
•	The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older

Estrogens with or without progestins should be prescribed at the lowest effective doses for the shortest duration consistent with the treatment goals for the individual woman.

Unintentional Secondary Exposure

Breast budding and breast masses in prepubertal females and gynecomastia and breast masses in prepubertal males have been reported following unintentional secondary exposure to Evamist by women using this product. In most cases, the condition resolved with removal of Evamist exposure. Women should ensure that children do not come into contact with the site(s) where Evamist is applied. Healthcare providers should advise patients to strictly adhere to recommended instructions for use.

Evamist (estradiol transdermal spray) is an estrogen indicated for the treatment of moderate to severe vasomotor symptoms due to menopause.

Evamist should not be used in women with undiagnosed abnormal genital bleeding; known, suspected, or history of breast cancer; known or suspected estrogen-dependent neoplasia; active deep vein thrombosis, pulmonary embolism, or history of these conditions; active or recent arterial thromboembolic disease; liver dysfunction or disease; or known or suspected pregnancy.

In a clinical trial with Evamist the most common side effects were headache, breast tenderness, nipple pain, nausea, back pain and nasopharyngitis

Please see full prescribing information for Evamist, including boxed warnings.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.