Evamist.com – How Evamist® can help (estradiol transdermal spray)

A clinical study showed that Evamist significantly reduced the number and intensity of moderate-to-severe hot flashes in women experiencing menopause. In fact, Evamist can reduce the number of hot flashes by half within 4 weeks.¹

As with most estrogen therapies, you likely won’t feel better after only one dose of Evamist. Give it some time before reevaluating your symptoms. On average, women felt increasingly better every week that they continued therapy in the 12-week study.²

By reducing their number and their severity, hot flashes may be less likely to interrupt your everyday activities. That may mean less time spent fanning yourself and stripping off layers and more time to do what you want to do.

Continuous delivery of estrogen

Evamist delivers estrogen on a continuous basis over 24 hours.^1,2 When measuring the effects of medications, researchers monitor the levels of the medication in the bloodstream. The longer the medication stays at consistent levels in your bloodstream, the longer the medication is providing benefits.

Additionally, with Evamist, studies have shown that for an 8 AM dose, serum levels reach their peak between 2 AM and 6 AM.²

The estrogen (estradiol) in Evamist is chemically synthesized from a plant source.² This does not mean Evamist is safer or more effective than other hormone therapies. Find out more about what Evamist is made from.

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Important Safety Information

What is the most important information I should know about Evamist (an estrogen hormone)?

•	Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Evamist. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause.
•	Do not use estrogen alone to prevent heart disease, heart attacks, strokes or dementia (decline of brain function)
•	Using estrogen alone may increase your chances of getting strokes or blood clots
•	Using estrogen alone may increase your chance of getting dementia, based on a study of women 65 years or older
•	Do not use estrogens with progestins to prevent heart disease, heart attack or dementia
•	Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
•	Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years and older
•	You and your healthcare provider should talk regularly about whether you still need treatment with Evamist
•	The estrogen in Evamist spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed Evamist. Young children who are accidentally exposed to estrogen through contact with women using Evamist may show signs of puberty that are not expected (for example, breast budding)

Evamist is an estrogen hormone used after menopause to reduce moderate to severe hot flashes.

Evamist should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.

The most common side effects that may occur with Evamist are headache, breast tenderness, the common cold, nipple pain, back pain, nausea, and joint pain.

Please see full patient information for Evamist.

Please see full prescribing information for Evamist, including boxed warnings.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.