For the treatment of moderate-to-severe vasomotor symptoms due to menopause
Full Prescribing Information
  • Who should not use Evamist?

    Do not start using Evamist® (estradiol transdermal spray) if you:

    • Have unusual vaginal bleeding

      Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
    • Currently have or have had certain cancers

      Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use Evamist® (estradiol transdermal spray).
    • Had a stroke or heart attack

    • Currently have or have had blood clots

    • Currently have or have had liver problems

    • Have been diagnosed with a bleeding disorder

    • Are allergic to Evamist or any of its ingredients

    • Think you may be pregnant

      Evamist® (estradiol transdermal spray) is not for pregnant women. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not use Evamist if the test is positive and talk to your healthcare provider.

    Before you use Evamist® (estradiol transdermal spray), tell your healthcare provider if you:

    • Have any unusual vaginal bleeding

      Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any vaginal bleeding to find out the cause.
    • Have any other medical conditions

      Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
    • Are going to have surgery or will be on bed rest

      Your healthcare provider will let you know if you need to stop using Evamist® (estradiol transdermal spray).
    • Are breast feeding

      The hormone in Evamist® (estradiol transdermal spray) can pass into your breast milk.

    Tell your healthcare provider about all the medicine you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Evamist® (estradiol transdermal spray) works. Evamist may also affect how your other medicines work. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

  • What should I avoid while using Evamist?

    • Do not allow others to make contact with the area of skin where you applied Evamist® (estradiol transdermal spray)
    • Because Evamist contains alcohol, which is flammable, avoid fire, flame, or smoking until the area of your skin where you have applied Evamist has dried
  • What are the possible side effects of Evamist?

    Side effects are grouped by how serious they are and how often they happen when you are treated.

    Serious, but less common side effects include:

    • heart attack
    • stroke
    • blood clots
    • dementia
    • breast cancer
    • cancer of the lining of the uterus (womb)
    • cancer of the ovary
    • high blood pressure
    • high blood sugar
    • gallbladder disease
    • liver problems
    • changes in your thyroid hormone levels
    • enlargement of benign tumors of the uterus (“fibroids”)

    Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

    • new breast lumps
    • unusual vaginal bleeding
    • changes in vision or speech
    • sudden new severe headaches
    • severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue

    Less serious, but common side effects include:

    • headache
    • breast pain
    • irregular vaginal bleeding or spotting
    • stomach or abdominal cramps, bloating
    • nausea and vomiting
    • hair loss
    • fluid retention
    • vaginal yeast infection

    These are not all the possible side effects of Evamist® (estradiol transdermal spray). For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effect that bothers you or does not go away. You may report side effects to Perrigo at 1-866-634-9120 or to FDA at 1-800-FDA-1088.

  • What can I do to lower my chances of a serious side effect with Evamist?

    Talk with your healthcare provider regularly about whether you should continue using Evamist® (estradiol transdermal spray).

    If you have a uterus, talk with your healthcare provider about whether the addition of a progestin is right for you.

    The addition of a progestin is generally recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

    See your healthcare provider right away if you get vaginal bleeding while using Evamist® (estradiol transdermal spray).

    Have a pelvic exam, breast exam, and mammogram (breast X-ray) every year unless your healthcare provider tells you something else.

    If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast exams more often.

    If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or if you use tobacco, you may have a higher chance of getting heart disease.

    Ask your healthcare provider for ways to lower your chances of getting heart disease.

  • How should I store Evamist?

    Store Evamist® (estradiol transdermal spray) at room temperature of 68°F to 77°F (20°C to 25°C). Do not freeze. Safely throw away medicine that is out of date or no longer needed.

  • Keep Evamist and all medicines out of the reach of children.

    Do not use Evamist® (estradiol transdermal spray) for conditions for which it was not prescribed. Do not give Evamist to other people, even if they have the same symptoms you have. It may harm them.

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Important Safety Information for EVAMIST (estradiol transdermal spray)

What is the most Important Information I should know about EVAMIST (an estrogen hormone)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EVAMIST. Vaginal bleeding after menopause may be a warning sign of cancer of the womb. Your healthcare provider should check any unusual vaginal bleeding to find the cause.
  • Do not use estrogen alone or with progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone or with progestins may increase your chances of getting strokes, blood clots, or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • The estrogen in EVAMIST spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed EVAMIST. Young children who are accidentally exposed to estrogen through contact with women using EVAMIST may show signs of puberty that are not expected (for example, breast budding).
  • You and your healthcare provider should talk regularly about whether you still need treatment with EVAMIST.

Do not start using EVAMIST if you have unusual vaginal bleeding; currently have or have had certain cancers; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have been diagnosed with a bleeding disorder; are allergic to EVAMIST or any of its ingredients; or think you may be pregnant

Before you use EVAMIST, tell your healthcare provider if you have any unusual vaginal bleeding; have any other medical conditions; are going to have surgery or will be on bed rest; are breast feeding

Tell your healthcare provider about all medicines you take. Some medicines may affect how EVAMIST works. EVAMIST may also affect how your other medicines work.

Talk to your healthcare provider about other treatments for your menopause symptoms if accidental exposure to EVAMIST cannot be avoided.

EVAMIST contains alcohol, which is flammable. Avoid fire, flame, or smoking until the area of your skin where you have applied EVAMIST has dried.

The most common s side effects associated with EVAMIST are headache, breast tenderness, nipple pain, back pain and nasopharyngitis.

These are not all the possible side effects of EVAMIST. For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.